CMV herpes family common virus, infects a large percentage of the population, 50-80%, antibodies IgG will circulate after primary infection
In de algemene populatie zorgt CMV nauwelijks voor symptomen, maar virus kan levensbedreigend zijn voor immunocompromised patients.
Primary infection in infancy: no morbidity. Latency. Hoge mortaliteit en morbiditeit.
Conventioal alloSCT: 40-60%, T cells not removed from the stem cell graft T cell depleted alloSCT: 95%, no T cells in the graft, 95% will develop reactivation