G- protein coupled receptors (GPCRs) wat weet je ervan?

    • One of most important targets for today's drugs 
    • very large family of regulatory proteins 
    • 7TM (trans-membrane) receptor structure 
    • central mechanism: GTP-GDP reaction 
    • five different key targets for G-proteins that translate the signal:
      • adenylate cyclase /cAMP
      • phospholipase 
      • ion channels 
      • Pho kinase 
      • mitogen-activated protein kinase 

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