2) axonopathy example 1: g-diketones
2,5-hexanedione:
metabolite of hexane
reacts with amino groups
crosslinking proteins

axonopathy example 2: carbon disulfide CS2
Vulcan rubber and viscose rayon industry distal axonopathy effects similar to hexane intermediate role for isothiocyanate formation covalent crosslinking “stocking and glove” distribution of effects

2) axonopathy example 3: organophosphate esters
used as pesticides: inhibit AChE (acute)
degeneration of neurons axonopathy (after 7-10 days), chikens are more sensitive then  rodents.
- TOCP = tri-ortho cresyl
phosphate
- mipafox
- leptophos
- others:
Effects like multiple sclerosis